Diagnosis: Diffuse large B-cell lymphoma (DLBCL)
Although nasopharyngeal masses are relatively uncommon, any such mass requires a thorough evaluation. While nasopharyngeal carcinoma represents the most common malignant neoplasm of the nasopharynx and central skull base, the differential diagnosis of a nasopharyngeal mass should be broad. In an adult, the differential diagnosis of a nasopharyngeal mass should include squamous cell carcinoma and histologic variants, nasopharyngeal carcinoma, adenocarcinoma, adenoid cystic carcinoma, sinonasal undifferentiated carcinoma, neuroendocrine carcinoma, lymphoma, plasmacytoma, rhabdomyosarcoma, malignant melanoma, olfactory neuroblastoma, and metastatic carcinoma.
Pathology Quiz Case 1: Diagnosis. Arch Otolaryngol Head Neck Surg. 2010;136(8):842-843. doi:10.1001/archoto.2010.118-b