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Resident's Page: Pathology
February 1999

Pathologic Quiz Case 1

Author Affiliations


Arch Otolaryngol Head Neck Surg. 1999;125(2):228-230. doi:

Tumefactive fibroinflammatory lesions is the term first used by Wold and Weiland1 to describe a fibrosclerosing lesion of the head and neck with a histologic appearance similar to Riedel thyroiditis, sclerosing mediastinitis, and retroperitoneal fibrosis. Grossly, the lesions are firm, gray-tan, and relatively well circumscribed but unencapsulated. Histologically, they are primarily composed of collagenized connective tissue with a patchy cellular infiltrate made up of lymphocytes, plasma cells, and occasional eosinophils. The fibroblasts lack cytologic atypia. At its periphery, the lesion may infiltrate skeletal muscle reminiscent of fibromatosis. Figure 3 and Figure 4 were obtained from the periphery and the center of the lesion, respectively.

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