A question long present in my mind was: What histologic changes occur after removal of the lining of the maxillary sinus? I sought information from various friends and acquaintances who are doing work on the sinuses. The reply from all was uniform and positive, namely, that a new lining composed of "low-grade, easily re-infected fibrous tissue" appeared following the radical operation on the antrum.
In discussing this question with Dr. Harris P. Mosher, about eight months ago, I said it would be a satisfaction to me, and, I thought, of interest to others, actually to see and to know what happened in the antrum following operation.
Dr. Mosher promptly suggested that such research be attempted and that dogs be used for the purpose. In subsequent experimental work, which was carried on in Dr. Mosher's laboratory at the Harvard Medical School, I was fortunate to have the assistance of Dr.
KNOWLTON CD, McGREGOR GW. HOW AND WHEN THE MUCOUS MEMBRANE OF THE MAXILLARY SINUS REGENERATESAN EXPERIMENTAL STUDY IN THE DOG. Arch Otolaryngol. 1928;8(6):647–656. doi:10.1001/archotol.1928.00620020679003