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PART III. GENERAL
1. Probability that the Hypothesis Favored Gives a True Picture of the Facts.—We have tested the hypothesis that otosclerosis depends on the concurrence in the zygote of a dominant gene in the X-chromosome and a dominant gene in an A-chromosome. We have seen that, on this hypothesis, all cases of occurrence of otosclerosis can be accounted for, and approximately the percentage of affected individuals found in a fraternity is that expected from the hypothesis. We have now to consider the probability that this hypothesis meets all the tests that can be applied to it.
(a) Relative Proportion of the Two Sexes Affected: We have seen that in the otosclerotic adults of our series the proportion of affected males to females is as 100:185. Thus, among otosclerotic persons the proportion of females is almost double that of males.
DAVENPORT CB, MILLES BL, FRINK LB. THE GENETIC FACTOR IN OTOSCLEROSIS. Arch Otolaryngol. 1933;17(4):503–548. doi:10.1001/archotol.1933.03570050493004