Although recently there have been reported cases of thrombosis of the cavernous sinus with recovery, the disease is still attended by such a high mortality that recovery may be considered a rarity. Early in 1939 Barnshaw1 reported the recovery of a patient, and later in the same year Seydell2 reported that of another. In both of these cases sulfanilamide was given. In June 1940 Morrison and Schindler3 reported a case with recovery in which sulfapyridine (2-[paraamino-benzenesulfonamido]-pyridine) was the chemotherapeutic agent. In their report there is included an excellent short summary of the disease.
Since the efficacy of sulfathiazole (2-sulfanilamidothiazole) in combating staphylococcic infections has been demonstrated, and since Staphylococcus is more often responsible for thrombosis of the cavernous sinus than any other organism, it is to be expected that this drug will be the one of choice for treatment of the condition in the future. At present, however, a review
WOLFE CT, WOLFE WC. THROMBOSIS OF THE CAVERNOUS SINUS WITH RECOVERY. Arch Otolaryngol. 1941;33(1):81–85. doi:10.1001/archotol.1941.00660030082007