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Article
January 1946

TISSUE CHANGES PRODUCED IN THE NASAL MUCOUS MEMBRANE OF NORMAL MICE BY PROLONGED LOCAL ADMINISTRATION OF SOME SOLUTIONS CONTAINING SULFONAMIDE COMPOUNDS

Author Affiliations

PHILADELPHIA
From the Research Institute of Cutaneous Medicine; Dr. John A. Kolmer, director.

Arch Otolaryngol. 1946;43(1):31-36. doi:10.1001/archotol.1946.00680050041007
Abstract

Numerous reports in the literature1 reveal differences of opinion regarding human tolerance of the solutions of sulfonamide compounds used in local treatment of the nasal mucous membrane. Recently, as a result of investigations of the physiologic range of the hydrogen ion concentration of the secretions of normal nasal tissues in situ (pH fluctuating between 5.5 and 6.5) and of the changes in it observed in the course of nasal and sinus diease of man, Fabricant2 proposed a new basis for the selection of local remedies to be administered intranasally. He stressed that markedly alkaline preparations usually exert an irritating effect on the nasal tissue, impairing the ciliary function and damaging the olfactory lining. The therapeutic problem has been to develop "a nontoxic medication, compatible with ciliary action," of the same hydrogen ion concentration as the nasal tissue and therefore "non-traumatizing to the mucous membrane." Furthermore, this author has stated that

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