INVESTIGATIONS of the effects of drugs on the mucous membranes of the nose have been encouraged by the fact that in various laboratory animals the nasal mucous membranes are easily accessible for such study and the effects of the drugs can be observed without the function of other vital organs being interfered with.
The basis for this type of experiment is complete orientation as to (1) the normal anatomy and histology of the animal in question and (2) knowledge of pathologic conditions as they are encountered spontaneously, i.e., in the course of the normal life under laboratory conditions or in the animal farms of the institutions without exposure to experimental factors. Rabbits are generally preferred in such work, but dogs, cats, mice, rats, ferrets and monkeys are frequently used.
Two groups of drugs are examined by this assay: (1) medicaments used locally in the treatment of nasal conditions and (2)
KELEMEN G, SARGENT F. NONEXPERIMENTAL PATHOLOGIC NASAL FINDINGS IN LABORATORY RATS. Arch Otolaryngol. 1946;44(1):24–42. doi:10.1001/archotol.1946.00680060035003