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December 1946

GINGIVAL HEMORRHAGE WITH ORAL MANIFESTATIONS IN HEREDITARY HEMORRHAGIC TELANGIECTASIASuccessful Control with Sclerosing Agent Sylnasol; Effect of Vitamin P and Nicotinic Acid; Role in Case Reported Which Was Observed Five Years

Author Affiliations

From the Department of Otolaryngology of the Good Hope Clinic.

Arch Otolaryngol. 1946;44(6):668-685. doi:10.1001/archotol.1946.00680060693003

GINGIVAL hemorrhage in hereditary hemorrhagic telangiectasia has been referred to frequently since Rendu,1 in 1896, first recognized this symptom complex and Osler,2 in 1901, created it as a clinical entity. However, a careful review of the literature has failed to disclose a detailed and illustrated report of a case of gingival hemorrhage and oral manifestations in this malady.

Goldstein3 in 1931 compiled a comprehensive historical review of oral hemorrhages in hereditary hemorrhagic telangiectasia from 1876 to 1930 inclusive, and for a more detailed bibliography the reader is directed to his article.

References to gingival hemorrhage with no further descriptive details have been made by numerous observers, but this symptom apparently, up to the present, has been recorded as a minor episode in conjunction with the more alarming nasal, oral and other hemorrhages which occur in the course of this disease.

Phillips4 (1908) mentioned a death from hemorrhage of the gum

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