DARIER'S disease is a rare but wellrecognized dermatologic disorder of unknown etiology characterized by papular, vesicular, and occasionally ulcerating lesions of the skin, particularly of the face, extremities, and inguinal region. Although it most frequently occurs in childhood, examples in infancy1 as well as adulthood2 have been recorded. The clinical course is slow but progressive, with apparently little effect upon general health except when secondary infection supervenes. Spontaneous remissions have been observed.
Examples of Darier's disease with involvement of the tongue, pharynx, esophagus, vulva, and oral mucosa have been described.* Although Lever6 cites Brünauer's5 reference to laryngeal lesions, we have been unable to find such a notation in his original publication.
The case to be presented represents, to our knowledge, the first recorded instance of Darier's disease of the larynx. In addition, it reemphasizes the value of biopsy with histologic examination of laryngeal lesions of unusual
FISHER ER, KYLER SL. DARIER'S DISEASE OF THE LARYNX. AMA Arch Otolaryngol. 1955;62(4):438–441. doi:10.1001/archotol.1955.03830040092018