Despite the many positive claims that have been made as to the efficacy of the various antivertiginous drugs now available, the search for a more effective compound with fewer side-reactions continues. Ideally, such medication, in addition to exhibiting a high degree of labyrinthine depression, should be relatively free of untoward sideeffects and possess an adequate duration of activity, thus eliminating the necessity for frequent administration. The preparation should, of course, be orally active and not interfere with the daily functions of the patient. Needless to say, such a compound has yet to be formulated.
One of the newer drugs suggested for use in disturbances of labyrinthine function and associated disorders is meclizine hydrochloride (Parachloramine, Postafene). Chemically, it is the dihydrochloride of 1 -p -chlorobenzhydryl-4-m-methylbenzylpiperazine, having the accompanying structural formula.
This compound has been found to possess antihistaminic and anticholinergic properties, either activity theoretically having some potential therapeutic value
GUTNER LB, GOULD WJ, HANLEY JS. Effect of Meclizine Hydrochloride (Bonamine) upon Vestibular FunctionObservations with Notes on Its Value in Comparison with Cyclizine Hydrochloride (Marezine) and Dimenhydrinate (Dramamine). AMA Arch Otolaryngol. 1955;62(5):497–503. doi:10.1001/archotol.1955.03830050039009