In ear, nose, and throat practice, as in medicine in general, modern concepts of endocrinology have diverted attention from its older knowledge. These revised concepts often have totally disregarded the significance of other pertinent factors, especially those related to the problem of metabolism. The situation, in this connection, is precisely expressed by Simpson,1 in reporting on some recent advances in endocrinology:
We have perhaps been rather dazzled by the influence of new hormones on the symptomatology of disease processes, and it might be argued by the pragmatic physician, or humanitarian, that successful therapy is the end-object of all medical research, but this conception certainly cannot replace the need for a deeper understanding of the causation of disease and its course.
The present study was undertaken because the problems entailed have been insufficiently dealt with in modern medical practice. "It would be a great mistake," as Simpson emphasized, "to ignore
HOLLENDER AR. Hypometabolism in Relation to Ear, Nose, and Throat Disorders. AMA Arch Otolaryngol. 1956;63(2):135–141. doi:10.1001/archotol.1956.03830080021006