Primary amyloid deposits occur in many parts of the body, including the skin, tongue, heart, pharynx, urethra, bladder, and respiratory tract. Laryngotracheal sites are the commonest, and primary amyloid tumors of the larynx and trachea are not so rare as they were once believed to be. In the past several years a sufficient and increasing number of reports have appeared in the literature to attest to the fact. However, there does not seem to be any unanimity of opinion regarding the etiology, pathology, and treatment of this lesion, which presents definite diagnostic and therapeutic problems.
Stark and New13 reviewed the case records of all the patients given the diagnosis of amyloid degeneration of the larynx at the Mayo Clinic up to 1948. The diagnosis of amyloid degeneration was confirmed microscopically in 15 of these cases, which constitute one of the largest series published. We have reviewed the surgical files
FIGI FA, BERMAN HL. Amyloid Tumors of the Larynx and TracheaReview of Nine Cases with Detailed Report of One. AMA Arch Otolaryngol. 1957;65(3):214–216. doi:10.1001/archotol.1957.03830210012002