Histological sections of the organ of Corti show in some cases a very pronounced outward bending of Reissner's membrane and in other cases just the opposite, namely, an inward bending. This has brought up the question of whether or not a disease of the inner ear may produce a pressure variation in the endolymphatic duct. If such a pressure variation were present, it should show up in the chemical content of the endolymphatic fluid.
Interest in this question was enhanced by the findings of Smith1 and Smith, Lowry, and Wu,2 who found that the chemical constitution of the endolymph is quite different from the constitution of other body fluids.
The question today is this: Are innerear diseases a consequence of changes in the chemistry of the endolymph or are inner-ear diseases rather produced by changes in the cell structure of the organ of Corti? A differentiation of the
von BÉKÉSY G, LEMPERT J. Method for Collecting Samples of Endolymph from the Vestibular Canal Without Contamination. AMA Arch Otolaryngol. 1958;68(1):33–36. doi:10.1001/archotol.1958.00730020037005