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June 1967

Leukemic Involvement of Larynx

Author Affiliations

Ann Arbor, Mich
From the departments of pathology and otorhinolaryngology, University of Michigan Medical Center, Ann Arbor, Mich. Dr. Shilling was fellow in the departments of pathology and otorhinolaryngology at the time this study was done.

Arch Otolaryngol. 1967;85(6):658-665. doi:10.1001/archotol.1967.00760040660013

INFILTRATES of leukemic cells in the larynx may produce clinical symptoms and signs, the importance of which must be recognized by the clinician. Warthin,1 in 1909, reported a case of acute laryngeal obstruction secondary to infiltration by cells of granulocytic leukemia which resulted in the death of the patient. In 1936, Love2 reported five examples of leukemic involvement of the larynx and briefly described the histopathological findings. The purpose of this study was to assess the larynx in patients with leukemias and malignant lymphomas, particularly in respect to pathogenesis and severity of lesions. It was hoped that such a clinicopathological study would more clearly delineate the clinical manifestations and implications.

Materials and Methods  During a period of five months, 19 patients with leukemia or generalized lymphoma had necropsies at The University of Michigan Medical Center. The larynges of these patients were removed intact with epiglottis and several

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