THE ROLE of preoperative irradiation in the management of laryngeal carcinoma is one of the most promising and yet debatable subjects before us at the present time. We find ourselves in the dilemma of attempting to decide when to intelligently use such therapy, at a time when reports of sufficiently large, and controlled series of patients treated by this form of therapy are unavailable. Accordingly, it would seem desirable, to survey the recent literature regarding this form of therapy as it pertains to carcinoma of the larynx specifically and head and neck surgery in general.
On the surface, it would seem that the use of combined irradiation and surgery would be advantageous by the simple principle that two modalities of treatment would be better than one. Unfortunately, it is not nearly this simple. Numerous factors must be considered in prognosticating whether, in individual cases, the combination of irradiation and surgery
Reed GF. Preoperative Irradiation in Laryngeal Carcinoma. Arch Otolaryngol. 1967;86(3):318–325. doi:10.1001/archotol.1967.00760050320014