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January 1968

Inner Ear Pathology in Deafness Due to Maternal Rubella

Author Affiliations

Nashville, Tenn
From the Division of Otolaryngology and the Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tenn.

Arch Otolaryngol. 1968;87(1):22-28. doi:10.1001/archotol.1968.00760060024005

BETWEEN THE YEARS 1939 and 1941 an epidemic of rubella swept Australia and Tasmania. The first to recognize the teratogenic effects of maternal rubella as a cause of fetal abnormalities was Gregg in 1941. Shortly thereafter in 1943 Swan and his colleagues,1 described deaf mutism as one of the more frequently occurring anomalies in prenatal rubella. A multitude of clinical studies have followed and numerous clinical cases of deafness have been well documented. The recent epidemic that spread across the United States during the years 1963, 1964, and 1965 brought a renewed interest in the general problem and undoubtedly will provide additional temporal bones for histopathological study. There have been several reports of clinical pathological studies of the temporal bones from fetus and from infants, but the majority of these were normal. There remains a sparsity of documented cases of deafness with clinical and pathological correlative studies. Even in

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