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January 1968

Chronic Ulcerative PharyngitisRadiographic Studies of Progressive Dysphagia in Five Patients

Author Affiliations

Bethesda, Md
From the Oral Development Section (Dr. Bosma), the Oral Medicine and Surgery Branch (Dr. Graykowski), and the Human Genetics Branch (Dr. Trygstad) of the National Institute of Dental Research, National Institutes of Health, Bethesda, Md. Dr. Graykowski is now at the US Public Health Service Hospital, San Francisco. Dr. Trygstad is a postdoctoral research fellow, at the University of Wisconsin School of Medicine, Madison, Wis.

Arch Otolaryngol. 1968;87(1):85-96. doi:10.1001/archotol.1968.00760060087017

CHRONIC ulcerative pharyngitis is a condition found in association with the necrotizing type of aphthous stomatitis designated as periadenitis by Sutton.1 This condition may be accompanied by chronic inflammatory processes in other organs, including the eyes, joints, urethra and genitalia, rectum and anus, and the central nervous system (CNS).2 This spectrum of involvement is often designated as Behcet's syndrome.3 Cutaneous ulcerations, erythema nodosum and thrombophlebitis are also described. These variably disseminated inflammatory lesions are of unknown etiology. They are generally suppressed in part by adrenocorticosteroid medications.4 Comparable syndromes of chronic inflammation of mouth, eyes, skin, urethra and joints are found in Reiter's disease and in the Stevens-Johnson form of erythema multiforme.

From the subjects of a continuing study of aphthous stomatitis at the Clinical Center, National Institutes of Health (NIH),5,6 five patients with severe pharyngeal involvement were selected to illustrate their unusual forms of pharyngeal

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