August 1969

Laryngeal Injection of Teflon PasteReport of a Case With Postmortem Study of the Larynx

Author Affiliations

From the Department of Otolaryngology (Dr. Harris) and the Department of Anatomic Pathology (Dr. Hawk), the Cleveland Clinic Foundation, Cleveland.

Arch Otolaryngol. 1969;90(2):194-197. doi:10.1001/archotol.1969.00770030196021

IN 1962, Arnold1 proposed the intracordal injection of Teflon granules suspended in glycerin for the treatment of vocal cord disability, particularly that related to hemiparesis. Injection of a foreign material into the larynx to improve speech had been first reported more than 50 years previously. Paraffin,2 bone paste,3 silicone rubber,4 glycerin,5 and silicone have all been used as agents.

Recently, Teflon granules, namely PTFE paste for injection (modified polytetrafluoroethylene, 50% weight, in glycerin), has become a favored implant agent, but its use is permitted only for investigational purposes by the Federal Food and Drug Administration.

In the case reported in this paper the patient died of carcinoma of the breast, more than two years after laryngeal injection of PTFE for the treatment of dysphonia, and postmortem examination of the larynx was performed. There have been reports of only two other cases that have had such

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