Microembolization of the cochlear vessels with a suspension of barium sulfate produces a decrease in the cochlear potential, eighth nerve action potential, and cochlear blood flow. One vasodilating agent, phenoxybenzamine hydrochloride (an αadrenergic blocking agent) appears to inhibit the deleterious effects of cochlear microembolization. The mechanism of this protection appears to be the prevention of reflex vasospasm in response to microembolization. Histopathologic examination of the temporal bones of the microembolized chronic animals reveals dilatation of the cochlear duct, degeneration of the organ of Corti and stria vascularis, and proliferation of fibrous and bony tissue into the cochlear lumen.
Suga F, Preston J, Snow JB. Experimental Microembolization Of Cochlear Vessels. Arch Otolaryngol. 1970;92(3):213–220. doi:10.1001/archotol.1970.04310030003002