A patient with hereditary angioneurotic edema was given prophylactic treatment with ε-aminocaproic acid (EACA), a plasminogen inhibitor, at the time of removal of a benign parotid tumor. In spite of the fact that such patients are prone to develop angioedema of the upper airway following trauma to the head and neck, such as occurs with surgery or endotracheal intubation, this patient developed no serious angioedema.
Otolaryngologists should be aware of the possible occurrence of hereditary angioneurotic edema, its poor prognosis, and the potential of preventing attacks by administration of EACA at the time of surgery.
Johns ME, Vanselow NA, Boles R. Hereditary Angioneurotic EdemaTreatment with ε-Aminocaproic Acid During Surgery. Arch Otolaryngol. 1974;99(5):388–389. doi:10.1001/archotol.1974.00780030400016