Hyperbaric oxygen used in the treatment of 14 patients with intractable osteonecrosis of the mandible produced a favorable response in relief of pain, elimination of extraoral draining sinus tracts, the return of osseous union in areas of the abnormal fracture, and the rapid dissolution of sequestrum without suppuration, so that further loss of hard and soft tissue was minimized.
This treatment is a more conservative approach in the management of osteoradionecrosis.
Mainous EG, Hart GB. Osteoradionecrosis of the MandibleTreatment With Hyperbaric Oxygen. Arch Otolaryngol. 1975;101(3):173–177. doi:10.1001/archotol.1975.00780320031007