• Four malignant tumors and one benign in a 76-year-old man appeared. Three of the neoplasms were in the respiratory system, and one was a bladder carcinoma; all were linked to heavy smoking habits. The patient underwent immunologic investigations consisting of in vivo testing for cutaneous reactivity, in vitro lymphocyte blastogenesis studies, Tand B-cell level studies, and serum immunoglobulin level studies. The studies have demonstrated anergy to recall antigens, decreased lymphocyte responses to phytohemagglutinin, and low levels of peripheral T-lymphocytes. The serum immunoglobulins were at the upper limit of the normal. The relationship between the patient's immunologic status and the occurrence of multiple primary neoplasms is discussed.
(Arch Otolaryngol 103:550-552, 1977)
Goldsher M, Bartal A, Eliachar I, Robinson E. Laryngeal Carcinoma Associated With Multiple Additional Primary TumorsImmunologic Studies. Arch Otolaryngol. 1977;103(9):550-552. doi:10.1001/archotol.1977.00780260080012