• Sodium fluoride has been demonstrated by spectrophotometric experiment to have an inhibitory effect on the hydrolyzing action of α-chymotrypsin. Sodium fluoride in moderate therapeutic dosage possibly can retard or completely inhibit the activity of bone-resorbing enzymes in the otospongiotic focus, thus retarding or arresting active expansion of a focus and resulting in stabilizing or arresting the progression of sensorineural hearing loss that is associated with otospongiosis.
(Arch Otolaryngol 106:260-261, 1980)
Kacker SK, Shambaugh GE. Effect of Fluoride on α-Chymotrypsin. Arch Otolaryngol. 1980;106(5):260–261. doi:10.1001/archotol.1980.00790290012005