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The first edition of this textbook of pharmacology and therapeutics was published in 1940. Since that time it has become the standard and classic text of pharmacology around the world. The sixth edition has been carefully written, organized, and edited, as in past editions. There are 70 chapters and three appendices, half of which have been rewritten and the rest updated. A new section has been added on toxicology.
The chapters on local anesthetics and antihistamines provide a historical perspective and an updated evaluation of mechanism of action, effectiveness, and toxicity. Section XIV is devoted to antimicrobial agents. It is quite exhaustive and will serve as a reference source for an in-depth understanding of antibiotic use. Section XIII, on antineoplastic agents, has an excellent introduction reviewing the cell cycle and site of chemotherapeutic drug action that should be reviewed by all otolaryngologists interested in the care of cancer patients.
JOHNS ME. The Pharmacological Basis for Therapeutics. Arch Otolaryngol. 1981;107(5):325. doi:10.1001/archotol.1981.00790410063020