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To the Editor.—I read with interest the article entitled "The Ototoxicity of Topically Applied Povidone-Iodine Preparations," by Morizono and Sikora that was published in the April Archives (1982;108:210-213).
I am questioning some of the conclusions of the authors. Unfortunately, they do not totally describe the scrub being tested. I believe it is a false assumption that only the potentially harmful ingredient is the active ingredient. Often, the detergent also carries with it the potential of ototoxicity. This is particularly true of the various povidone-iodine scrub solutions available. Some contain active ionic detergents that are known to be ototoxic, while others have much less potentially dangerous nonionic detergents. I believe the authors should have stated which detergent was being tested rather than using a generic term.
In the absence of such information, their conclusion that povidone-iodine is ototoxic must be questioned, since the only difference between the preparations was the
AUSTIN DF. Ototoxicity of Detergents. Arch Otolaryngol. 1982;108(12):808. doi:10.1001/archotol.1982.00790600052013