January 1988

Anaplastic Thyroid CarcinomaAssociation With Differentiated Thyroid Cancer

Author Affiliations

From the Departments of Otorhinolaryngology and Communicative Sciences (Drs Spires and Miller) and Pathology (Dr Schwartz), Baylor College of Medicine, Houston. Dr Spires is now in private practice in Mobile, Ala; Dr Miller is now with Tulane University School of Medicine, New Orleans.

Arch Otolaryngol Head Neck Surg. 1988;114(1):40-44. doi:10.1001/archotol.1988.01860130044012

• Fourteen cases of anaplastic thyroid carcinoma (ATC) treated at Baylor College of Medicine, Houston, during a 19-year period were reviewed. There was a 1.3:1 female preponderance, and the median patient age was 62 years. Ten (71%) of the anaplastic tumors either followed or occurred simultaneously with a well-differentiated thyroid carcinoma. This finding adds support to the theory that ATC usually results from the transformation of well-differentiated thyroid carcinoma. A combination of surgery, radiation therapy, and chemotherapy was utilized for most patients. In this series of patients, the median duration of survival was four months following diagnosis, with only three patients (21%) alive at one year. Despite aggressive therapy, the prognosis for ATC remains poor.

(Arch Otolaryngol Head Neck Surg 1988;114:40-44)