February 1988

Pigmentation, Anesthesia, Behavioral Factors, and Salicylate Uptake

Author Affiliations

From the Section of Otolaryngology, Department of Surgery, Yale University School of Medicine, New Haven, Conn (Drs Jastreboff, Issing, and Sasaki) and the Department of Psychology, University of Massachusetts at Boston, Harbor Campus (Dr Brennan).

Arch Otolaryngol Head Neck Surg. 1988;114(2):186-191. doi:10.1001/archotol.1988.01860140084027

• In four experiments, 54 pigmented rats were used to examine the time course of sodium salicylate uptake in serum, cerebrospinal fluid, and perilymph. Subjects were tested under sodium pentobarbital anesthesia or while conscious. Compared with previously reported data from albino rats, pigmented subjects generally showed increased salicylate uptake. Moreover, the data suggested two different, time-dependent clearance mechanisms in conscious animals not observed in anesthetized rats. Daily injections of salicylate did not produce an accumulation of salicylate in serum. Systematically higher levels of salicylate were observed in perilymph compared with cerebrospinal fluid. Behavioral procedures, including water deprivation and conditioned suppression of ongoing drinking levels, had no effect on salicylate levels.

(Arch Otolaryngol Head Neck Surg 1988;114:186-191)