June 1988

Efficacy of Defibrinogenation and Steroid Therapies on Sudden Deafness

Author Affiliations

From the Osaka (Japan) University School of Medicine (Drs Kubo, Matsunaga, and Asai); Tohoku (Japan) University School of Medicine (Drs Kawamoto and Kusakari); Tokyo University School of Medicine (Drs Nomura and Oda); Nagoya (Japan) University School of Medicine (Drs Yanagita and Niwa); and Kyushu (Japan) University School of Medicine (Drs Uemura and Komune).

Arch Otolaryngol Head Neck Surg. 1988;114(6):649-652. doi:10.1001/archotol.1988.01860180063031

• Effects of defibrinogenation therapy and steroid therapy for sudden deafness were compared by paired double-blind testing. The average hearing recovery for five frequencies (250 to 4000 Hz) was more than 30 dB; overall improvement rate was 57.3% (47/82) for the patients assigned to defibrinogenation therapy and 38.7% (31/80) for the patients assigned to steroid therapy. Thus, the former treatment resulted in significantly better hearing recovery.

(Arch Otolaryngol Head Neck Surg 1988;114:649-652)