In Reply.—We thank Drs Gates and Garner for their comments. It has been clearly shown that when used for intermittent claudication, the beneficial effect of pentoxifylline may take several weeks to become apparent. We do not know the effects of this drug in skin flap survival, and this may not necessarily be equivalent.
Our study was designed after reports in the literature showing enhanced skin flap survival in rats, with pentoxifylline given seven to ten days postoperatively and starting 24 hours preoperatively or less.1,2 We intended to extend similar treatment schedules in a different animal model, the domestic pig. We do agree that there is a potential clinical benefit of this drug and that it deserves further work.
We cannot comment on the result of Drs Gates' and Garner's study since the animal model used was not mentioned. We look forward to seeing more articles regarding work with
HODGSON RS, BRUMMETT RE, COOK TA. Effects of Pentoxifylline on Experimental Skin Flap Survival-Reply. Arch Otolaryngol Head Neck Surg. 1988;114(6):681. doi:10.1001/archotol.1988.01860180095046