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Article
September 1988

Effects of Oxypherol-ET on Random Skin-Flap Survival in the Swine Model

Author Affiliations

From the Department of Otolaryngology—Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City. Dr Maves is now with the Department of Otolaryngology—Head and Neck Surgery, St Louis University.

Arch Otolaryngol Head Neck Surg. 1988;114(9):973-976. doi:10.1001/archotol.1988.01860210039011
Abstract

• Random skin flaps are an important and frequently used technique in head and neck reconstruction. Fluorocarbons (Oxypherol-ET) have a low viscosity and high oxygen solubility that allow them to enhance the microcirculation and reduce skin-flap necrosis. These properties were evaluated using the swine model. Group 1 (four flaps) served as controls, with no hematologic or pharmacologic manipulations. Group 2 (16 flaps) had 20% of their blood volume removed and replaced with an equal amount of lactated Ringer's solution. Group 3 (16 flaps) also had 20% of their blood volume removed and replaced with an equal amount of Oxypherol-ET. Necrosis in group 1 (controls) averaged 32.6%; in group 2 (lactated Ringer's solution), 27.8%; and in group 3 (OxypherolET), 8.34%. This study has shown a statistically significant enhancement of random skin-flap survival in the swine model with Oxypherol-ET.

(Arch Otolaryngol Head Neck Surg 1988;114:973-976)

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