• We treated 94 patients with advanced head and neck cancer with a combined-modality protocol that included induction chemotherapy followed by surgery with and without radiotherapy. With a minimum follow-up of 3½ years, 33 (35%) of the patients were alive and disease free. Thirty (32%) of the patients died of recurrent head and neck cancer. Complete response to chemotherapy and initial tumor bulk correlated with prolonged disease-free survival. Site of disease had no effect. There appeared to be no advantage to the use of routine post-operative radiotherapy in these advanced tumors.
(Arch Otolaryngol Head Neck Surg 1989;115:68-73)
Spaulding MB, Loré JM, Sundquist N. Long-term Follow-up of Chemotherapy in Advanced Head and Neck Cancer. Arch Otolaryngol Head Neck Surg. 1989;115(1):68-73. doi:10.1001/archotol.1989.01860250070030