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At the recent meeting of the Fifth International Symposium of the American Academy of Facial Plastic and Reconstructive Surgery in Toronto, Canada, Dean Toriumi, MD, and coworkers, Chicago, Ill, presented an experimental study evaluating the tissue response of ethyl-2-cyanoacrylate (Krazy Glue) and butyl-2-cyanoacrylate (Histoacryl) when used to glue a bone graft to cartilage. A rabbit ear model was used employing ethyl-2-cyanoacrylate on the right ear and butyl-2-cyanoacrylate on the left ear. Histologic analysis at 1 and 2 weeks, and at 1, 3, 6, and 12 months revealed the following: (1) Ethyl-2-cyanoacrylate produced an intense acute inflammation with some tissue necrosis and sterile abscess formation. This reaction subsided only to be replaced by chronic foreign body giant cell reaction with adhesive-filled inclusions. The adhesive was completely degraded within 1 year. (2) Butyl-2-cyanoacrylate produced a mild foreign body giant cell reaction that gradually diminished but, in some cases, persisted for over 1
ADAMS BJS. Cyanoacrylate for Bonding Bone and Cartilage: An Experimental Study. Arch Otolaryngol Head Neck Surg. 1990;116(1):13. doi:10.1001/archotol.1990.01870010015003