January 1990

Augmented Gentamicin Ototoxicity Induced by Vancomycin in Guinea Pigs

Author Affiliations

From the Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery (Dr Brummett and Messrs Jacobs and Stokes and Ms Kempton) and the Department of Pharmacology (Dr Fox and Ms Richmond), Oregon Health Sciences University, Portland, Ore.

Arch Otolaryngol Head Neck Surg. 1990;116(1):61-64. doi:10.1001/archotol.1990.01870010065019

• Vancomycin has been reported to be an ototoxic drug in the clinical literature. At best, this literature is confusing. There are no reports of ototoxicity of vancomycin in experimental animals, even when it is administered concurrently with ethacrynic acid, a drug known to augment the ototoxic effect of most other ototoxic drugs. In most of the cases of permanent ototoxicity that have been reported, the patient was treated with an aminoglycoside antibiotic as well as vancomycin. This study found no evidence of vancomycin ototoxicity in guinea pigs, but found that vancomycin greatly enhanced the ototoxicity of gentamicin.

(Arch Otolaryngol Head Neck Surg. 1990;116:61-64)