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February 1990

Regional Radiotherapy as Adjuvant Treatment for Head and Neck Malignant MelanomaPreliminary Results

Author Affiliations

From the Departments of Clinical Radiotherapy (Drs Ang, Peters, Maor, Wendt, and Morrison) and Head and Neck Surgery (Drs Byers and Goepfert), The University of Texas M. D. Anderson Cancer Center, Houston; and Division of Radiation Oncology, University of Iowa Hospitals, Iowa City (Dr Hussey).

Arch Otolaryngol Head Neck Surg. 1990;116(2):169-172. doi:10.1001/archotol.1990.01870020045012

• From 1983 through 1988, 83 patients with high-risk cutaneous malignant melanoma (primary lesion thicker than 1.5 mm or palpable lymphadenopathy) of the head and neck region were enrolled in a study designed to assess the efficacy of a few large doses of radiation (24 to 30 Gy in 4 to 5 fractions). The actuarial 2-year locoregional control rates for the three groups were 95%, 90%, and 83%, respectively. Corresponding survival rates were 80%, 71%, and 69%. The majority of failures were due to distant metastases. Locoregional control rates were better than those reported earlier with surgery alone for comparable patients. The treatment morbidity was minimal.

(Arch Otolaryngol Head Neck Surg. 1990;116:169-172)