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September 1991

Interstitial Laser Phototherapy Guided by Magnetic Resonance Imaging for Palliative Treatment of Nonresectable Carcinoma: First Human Case Report

Author Affiliations

San Diego, Calif.

Arch Otolaryngol Head Neck Surg. 1991;117(9):957. doi:10.1001/archotol.1991.01870210019003

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At the recent Western Section meeting of the Triologic Society in Santa Barbara, Calif, Dan J. Castro, MD, UCLA, presented the first case report using real-time magnetic resonance imaging (MRI) guidance of neodymium: yttrium aluminum garnet interstitial laser treatment of neck cancer. Coauthors were Romaine F. Saxton, PhD, Robert B. Lufkin, MD, and Paul Ward, MD, also from UCLA, as well as Jacques Soudant, MD, Paris, France.

Recent studies have shown the ability of MRI of tumors to quantify laser-induced tissue damage. Interstitial laser phototherapy is a technique whereby laser energy is directly applied into tumors at variable depths. The advantage of this technique is that it allows treatment of deep and difficult-to-reach tumors. Their case report demonstrated the combination of these two new innovations. The 4-cm recurrent squamous cell carcinoma in a jugulodigastric node only partially responded to chemotherapy and quadrupled in size during the 3 weeks before phototherapy.

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