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February 1992

The Effect of Relaxin on Tissue Expansion

Author Affiliations

From the Department of Otolaryngology—Head and Neck Surgery, University of Washington, Seattle (Drs Kibblewhite and Larrabee), and the Virginia Mason Research Center, Seattle (Drs Kibblewhite and Sutton). Dr Kibblewhite is now with the Ear, Nose, and Throat Clinic, University Hospital—Shaughnessy Site, Vancouver, British Columbia.

Arch Otolaryngol Head Neck Surg. 1992;118(2):153-156. doi:10.1001/archotol.1992.01880020047014

• Relaxin is a 56-amino acid polypeptide that produces relaxation of the pubic ligament. Ten young male pigs were implanted with tissue expanders and osmotic pumps. The pumps in five animals contained recombinant human relaxin to produce a serum relaxin level of 1 ng/mL. The other five pumps contained saline. Repeated measurements of the pressure-volume expansion curves showed a significant decrease in the pressure needed to fill the expanders in the relaxin group compared with the control group. Dermal thickness in the control group and epidermal thickness in both control and experimental groups were increased on histomorphometric measurement. No adverse effects were seen in the relaxin group. Relaxin facilitates tissue expansion in pigs without affecting dermal thickness.

(Arch Otolaryngol Head Neck Surg. 1992;118:153-156)