• It is well known that the ototoxicity resulting from the use of aminoglycoside antibiotics in experimental animals can be augmented by intense sound. However, the dose-effect relationship of this interaction is not known. This study was designed to determine the shape of this dose-effect relationship in guinea pigs at sound intensities approaching those that would be experienced by patients receiving aminoglycoside antibiotics. We found a linear relationship between the probit of the percent of missing cochlear outer hair cells and decibel-A scale sound intensity when the animals were treated with kanamycin plus white noise ranging from 115 to 45 dBA.
(Arch Otolaryngol Head Neck Surg. 1992;118:498-500)
Brummett RE, Fox KE, Kempton JB. Quantitative Relationships of the Interaction Between Sound and Kanamycin. Arch Otolaryngol Head Neck Surg. 1992;118(5):498-500. doi:10.1001/archotol.1992.01880050044011