June 1995

Treatment of Experimental Frostbite With Pentoxifylline and Aloe Vera Cream

Author Affiliations

From the Division of Otolaryngology, Albany (NY) Medical College.

Arch Otolaryngol Head Neck Surg. 1995;121(6):678-680. doi:10.1001/archotol.1995.01890060076015

Objective:  To compare the therapeutic effects of systemic pentoxifylline and topical aloe vera cream in the treatment of frostbite.

Design:  The frostbitten ears of 10 New Zealand white rabbits were assigned to one of four treatment groups: untreated controls, those treated with aloe vera cream, those treated with pentoxifylline, and those treated with aloe vera cream and pentoxifylline.

Main Outcome Measures:  Tissue survival was calculated as the percent of total frostbite area that remained after 2 weeks.

Results:  The control group had a 6% tissue survival. Tissue survival was notably improved with pentoxifylline (20%), better with aloe vera cream (24%), and the best with the combination therapy (30%).

Conclusion:  Pentoxifylline is as effective as aloe vera cream in improving tissue survival after frostbite injury.(Arch Otolaryngol Head Neck Surg. 1995;121:678-680)