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March 1996

A Prospective, Double-blind, Randomized Study of the Effects of Perioperative Steroids on Palatoplasty Patients

Author Affiliations

From the Department of Otolaryngology–Head and Neck Surgery, University of California, Davis, Medical Center (Drs Senders, Sykes, and Brodie), and the Division of Otolaryngology–Head and Neck Surgery, University of Maryland Medical Center, Baltimore (Dr Emery).

Arch Otolaryngol Head Neck Surg. 1996;122(3):267-270. doi:10.1001/archotol.1996.01890150045008

Objective:  To determine whether perioperative steroids affect the outcome of patients who undergo palatoplasty.

Design:  A prospective, double-blind, randomized study.

Setting:  A university medical center.

Patients:  Twenty patients undergoing primary repair of a cleft palate.

Intervention:  A prospective double-blind technique was used to randomly assign patients to receive a placebo or dexamethasone sodium phosphate perioperatively.

Main Outcome Measure:  Patients were monitored for postoperative airway distress, fever, oral fluid intake, days of hospitalization, and wound healing.

Results:  The use of perioperative steroids was associated with shorter hospitalizations. No adverse sequelae from the administration of steroids were identified.

Conclusion:  In our current managed care environment, the use of perioperative steroids may play an important role in reducing health care costs.(Arch Otolaryngol Head Neck Surg. 1996;122:267-270)