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Article
November 1996

OK-432 Therapy for Lymphangiomas

Author Affiliations

From the Departments of Otolaryngology (Drs Smith and Bauman and Ms Burke), Radiology (Dr Sato), and Surgery (Dr Kimura) and the College of Pharmacy (Dr Poust), University of Iowa, Iowa City.

Arch Otolaryngol Head Neck Surg. 1996;122(11):1195-1199. doi:10.1001/archotol.1996.01890230041009
Abstract

Objective:  To assess the efficacy of OK-432 sclerotherapy in the treatment of lymphangiomas.

Design:  Nonrandomized trial; follow-up, 4 to 29 months.

Setting:  Academic tertiary referral medical center.

Patients:  Six children with presumed lymphangiomas; age range at initial treatment, 1 month to 7 years 10 months.

Intervention:  Fluoroscopically guided cyst aspiration, cystography, and injection of OK-432.

Outcome Measures:  Clinical and radiographic comparisons before and after therapy.

Results:  Complete response in 2 macrocystic lymphangiomas; no response in 3 microcystic lymphangiomas; and no response in 1 venous malformation.

Conclusion:  OK-432 sclerotherapy may be effective treatment for macrocystic lymphangiomas.Arch Otolaryngol Head Neck Surg. 1996;122:1195-1199

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