To devise an intensified treatment regimen for patients with advanced, resectable head and neck squamous cell carcinomas.
Phase I/II clinical trial consisting of perioperative cisplatin chemoradiotherapy, surgical resection, intraoperative radiotherapy, and postoperative cisplatin chemoradiotherapy.
The Ohio State University Comprehensive Cancer Center, Columbus.
Thirty-seven patients (median age, 63 years) with advanced oral cavity, oropharyngeal, or hypopharyngeal carcinomas.
The range of time at risk was 1 to 30 months (median, 21 months). Thirty of the 37 registered patients were analyzable; 11 have died (5 with distant metastases; 1 of lung carcinoma; and 5 were cancer-free); 2 experienced second primary tumors in the oral cavity (out of or adjacent to the previous radiotherapy portals). Treatment compliance was excellent (92%), morbidity was low, and excellent locoregional control was achieved.
The initial results are encouraging; the future strategy will intensify the systemic component of therapy based on results from concurrent laboratory studies.Arch Otolaryngol Head Neck Surg. 1997;123:139-144
Schuller DE, Grecula JC, Gahbauer RA, Bauer C, Au JL, Smith RE, Haller JR, Mountain RE, Young DC, Nag S. Intensified Regimen for Advanced Head and Neck Squamous Cell Carcinomas. Arch Otolaryngol Head Neck Surg. 1997;123(2):139-144. doi:10.1001/archotol.1997.01900020013002