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Clinical Problem Solving: Pathology
November 2004

Pathology Quiz Case 1—Diagnosis

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Copyright 2004 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2004

Arch Otolaryngol Head Neck Surg. 2004;130(11):1338. doi:10.1001/archotol.130.11.1338

Angiolymphoid hyperplasia with eosinophilia is a rare disease that is characterized by benign, locally proliferating lesions composed of vascular channels with a surrounding infiltrate of lymphocytes and eosinophils. The lesions occur predominantly in the skin of the head and neck area and appear clinically as persistent, pruritic, erythematous nodules that differ in size and tend to bleed after irritation.13 The term angiolymphoid hyperplasia with eosinophilia was first introduced by Wells and Whimster4 in 1969. Nowadays, angiolymphoid hyperplasia with eosinophilia, together with some other related vascular lesions, is classified under the general term epithelioid hemangioma.5

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