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Clinical Problem Solving: Pathology
May 2005

Pathology Quiz Case: Diagnosis

Author Affiliations
 

FREDERIC B.ASKINMDWILLIAM H.WESTRAMD

Arch Otolaryngol Head Neck Surg. 2005;131(5):466. doi:10.1001/archotol.131.5.466

Pleomorphic adenoma, also known as benign mixed tumor because of the presence of both epithelial and mesenchymal elements, is the most common salivary gland neoplasm. The most common site of origin is the major salivary glands, in particular the parotid gland. Pleomorphic adenoma arising from the minor salivary glands of the larynx is extremely rare. Dubey et al1 identified only 21 cases in the world literature. Within the larynx, the most common subsite of origin is the supraglottis, typically the epiglottis, likely because of the high concentration of minor salivary glands at the base of the tongue and vallecula. To our knowledge, there has been only a single previously reported case of pleomorphic adenoma occurring at the anterior commissure.2 Pleomorphic adenoma of the larynx, similar to that arising in the major salivary glands, can affect adults of any age but usually presents in the fourth through seventh decades of life. Presenting symptoms depend on the size and location of the lesion, with vocal disturbance or dyspnea being the most common.

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