Case Report/Case Series
March 2015

The Role of Tonsillectomy in the Treatment of Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS)

Author Affiliations
  • 1Department of Otorhinolaryngology–Head and Neck Surgery, Albert Einstein College of Medicine, Bronx, New York
  • 2Children’s Hospital at Montefiore, Bronx, New York

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Otolaryngol Head Neck Surg. 2015;141(3):272-275. doi:10.1001/jamaoto.2014.3407

Importance  Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) in children describes neuropsychiatric symptom exacerbations that relate temporally to streptococcal infections. Recent case reports suggest tonsillectomy may effectively reduce these symptoms; however, no consensus treatment guidelines exist. This study examines whether tonsillectomy improves neuropsychiatric symptoms in children with PANDAS who have incomplete response to antibiotic therapy.

Observations  Ten patients met strict diagnostic criteria for PANDAS. Comparisons were made between parental reports of symptom severity at diagnosis, after antibiotic treatment (in 10 patients), and after tonsillectomy (in 9). From a baseline severity score of 10, antibiotics alone improved symptoms to a median (interquartile range [IQR]) score of 8 (6.5-10.0) (P = .03). Nine children who subsequently underwent tonsillectomy reported symptom improvement in comparison with treatment with antibiotics alone, including those with no response to antibiotics. Symptom severity improved at all periods after tonsillectomy compared with antibiotics alone. The median score [IQR] 3 months postoperatively was 3 (0.0-6.5) (P = .01); 6 months postoperatively, 3 (0.0-5.0) (P = .02); 1 year postoperatively, 3 (0.0-5.0) (P = .02); and 3 years postoperatively, 0.5 (0.0-2.3) (P = .03). Four of the 9 had complete resolution after tonsillectomy.

Conclusions and Relevance  This PANDAS cohort whose neuropsychiatric symptoms did not respond sufficiently to antibiotics may have gained benefit from tonsillectomy.


Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) describes a clinical syndrome characterized by abrupt onset of obsessive compulsive disorder (OCD) and/or tic disorder temporally associated with group-A β-hemolytic streptococcal (GABHS) infection.1 The diagnostic criteria first described by Swedo et al2 in 1998 was based on an observational study of children diagnosed as having the poststreptococcal autoimmune entity Sydenham chorea (SC), a neuropsychiatric disorder often associated with rheumatic fever. While researchers continue to refine this diagnosis and propose additional working criteria, there is still little consensus regarding the treatment of this condition. Based on a presumed poststreptococcal autoimmune etiology, antibiotics and immunomodulatory therapies are currently the mainstay of treatment for PANDAS.3 Although tonsillectomy is a commonly used treatment option for recurrent streptococcal pharyngitis, it is not yet an accepted treatment modality for PANDAS. This study aims to examine whether tonsillectomy provides relief for PANDAS patients’ neuropsychiatric symptoms, and to document the effect on clinical severity over time.


This study was conducted as a retrospective medical chart review of 30 patients suspected as having PANDAS seen from 2006 to 2013 at our tertiary care children’s hospital in Bronx, New York. Institutional review board approval was given by The Children's Hospital at Montefiore. To supplement medical chart data, a 9-item questionnaire assessing medical history, timeline of neuropsychiatric symptoms, and symptom response to treatment was administered to parents of all potential participants. Oral consent was obtained, and no stipend was given to participants. Inclusion criteria were based on fulfillment of the 5 diagnostic standards as described by Swedo et al2 as follows: (1) presence of OCD and/or tic disorder, (2) pediatric onset (age 3 years to puberty), (3) episodic course of symptom severity, (4) association with GABHS, and (5) association with neurological abnormalities (motor hyperactivity or adventitious movements, eg, choreiform movements).

The 10 patients who met diagnostic criteria for PANDAS were contacted by phone after the procedure to further evaluate the historical timeline of their neuropsychiatric symptoms. Parents of the 9 patients who underwent tonsillectomy were also asked (at a mean follow-up of 4.6 years after surgery) to recall their child's symptoms at 3, 6, and 36 months after surgery. All of our data regarding timeline of symptoms were gathered retrospectively. A nonvalidated symptom severity scale was developed for our outcomes measurement. Parents were asked to consider the frequency and severity of their child’s symptoms at specific periods in the disease course and compare those symptoms with those at the point at which the symptoms were most severe. They were asked to report on a scale of 0 to 10 (with 0 representing no symptoms and 10 representing the most profound symptoms), the severity and frequency of symptoms prior to any initial treatments, after antibiotic treatment, and at 3-, 6-, 12-, and 36-month intervals after tonsillectomy. From these data, comparisons were made between symptom severity at the time of diagnosis, after treatment with antibiotics alone (10 patients), and after tonsillectomy (9 patients). We compared scores prior to intervention and after antibiotic treatment, and compared scores after tonsillectomy with scores after antibiotics alone. Symptom severity scores were not normally distributed, so they are reported as median (interquartile range [IQR]). Comparisons of symptom severity scores measured at the baseline, after antibiotic administration, and intervals after tonsillectomy of 3 months, 6 months, 1 year, and 3 years were compared using the Wilcoxon paired signed rank sum test. A 2-tailed α of .05 was used to denote statistical significance. Statistical analysis was performed with SPSS statistical software for Windows (version 20).


Our cohort consisted of 10 patients (8 boys and 2 girls). The average age of onset of the first neuropsychiatric symptoms was 6.5 years. Nine of 10 patients demonstrated tics, and 4 of 10 had psychiatric symptoms, such as anxiety or OCD traits. All of the patients had been treated with antibiotics in the past or were currently receiving antibiotic prophylaxis for recurrent streptococcus infections. In most cases, patients had been exposed to multiple antibiotics over a period of several months. However, the precise duration of each patient’s antibiotic course was unclear because it was frequently implemented outside of our institution. Nine of the 10 children underwent extracapsular tonsillectomy with adenoidectomy. One child, who had experienced partial resolution of symptoms during the first year of treatment with antibiotics, continued to receive antibiotic therapy alone. The total duration of follow-up for this child was 5 years.

The Table displays the compilation of the symptom severity scores across each patient’s treatment course. None of these children experienced spontaneous improvement prior to treatment with antibiotics. During antibiotic treatment, symptom severity scores decreased from a baseline of 10 to a median (IQR) score of 8 (6.5-10.0) (P = .03). Fifty percent of children showed no response to antibiotics, and no child exhibited a complete resolution of symptoms with antibiotics alone. All 9 children who underwent tonsillectomy, including those patients who did not have any response to antibiotic therapy alone, reported decreased symptom severity scores after tonsillectomy. Six of 9 children showed improvement in their symptoms 3 months after they had a tonsillectomy, 3 of whom reported a complete resolution of symptoms. The Figure shows that symptom severity scores improved at all measured time points after tonsillectomy when compared with antibiotics alone: 3 months posttonsillectomy, the symptom severity scores dropped to a median (IQR) of 3 (0.0-6.5) (P = .01); 6 months postoperatively, 3 (0.0-5.0) (P = .02); 12 months postoperatively, 3 (0.0-5.0) (P = .02); and 36 months postoperatively, 0.5 (0.0-2.3) (P = .03). At maximal follow-up (mean duration of follow-up, 2.2 years) all patients experienced a dramatic decrease in symptom severity. Four of the 9 children, including 2 patients who had no response to antibiotics, reported complete resolution of their neuropsychiatric symptoms. The single child who did not undergo tonsillectomy reported a symptom score as low as 2, but reported multiple exacerbations of neuropsychiatric symptoms requiring continued antibiotic prophylaxis. Similar episodes of worsening symptoms were not reported in any children after tonsillectomy.

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Symptom Severity Score Timeline and Analysisa
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Timeline of Median Symptom Severity Scores Showing a Decrease in Severity at All Time Points After Tonsillectomy

PANDAS has been a controversial disease entity since the original 1998 publication by Swedo et al2 at the US National Institute of Mental Health describing a subset of children with GABHS-associated exacerbations of OCD and tic symptoms.4 The controversy behind the diagnosis stems from the broad array of attributable symptoms, the prevalence of streptococcal infections in the pediatric population, and the lack of an identifiable biomarker. Many children diagnosed as having PANDAS have neuropsychiatric comorbidity, including movement disorders, anxiety, emotional lability, and attention-deficit/hyperactivity disorder.4 Furthermore, the underlying cause of the disease continues to be a matter of debate, confounding the development of a standard treatment algorithm.5 Currently, the most widely accepted hypothesis states that an autoimmune poststreptococcal process in susceptible children leads to development of antineuronal antibodies that cross-react with the basal ganglia, resulting in manifestation of behavioral and motor disturbances.6 Because the proposed autoimmune mechanism resembles that of SC, it has led to experimental trials with prophylactic antibiotics and immunomodulatory agents such as intravenous immunoglobulin (IVIG) and plasma exchange (PE).3 Both IVIG and PE were successfully used by Perlmutter et al7 to decrease symptom frequency in patients who met PANDAS diagnostic criteria. However, because immunomodulatory therapies carry considerable morbidity and the study has not been replicated, use of this treatment modality has not been widely accepted. Currently, treatment guidelines do not exist, although some have recommended antibiotic treatment for GABHS infections with standard nonpharmacologic and pharmacologic treatment of persistent OCD or tic disorder symptoms with selective serotonin reuptake inhibitors and cognitive-based therapy.8 Studies to evaluate the effectiveness of antibiotics for treatment of acute symptoms and for prophylaxis against future exacerbations have shown equivocal results.911

Recent case reports provide anecdotal evidence that children with PANDAS who undergo tonsillectomy experience fewer subsequent streptococcal infections and neuropsychiatric symptoms.3 From 2001 to 2010, 5 case reports or series4,5,1214 described a total of 7 children with PANDAS who experienced improvement of symptoms following tonsillectomy. One series4 described frequent recurring streptococcal infections despite antibiotic treatment in 2 siblings, who both experienced eradication of OCD and tics within 11 months of tonsillectomy. These reports suggest that adenotonsillectomy may be a valuable treatment option for children with PANDAS.

This study investigates the impact of tonsillectomy on neuropsychiatric symptoms in patients with PANDAS who experienced incomplete response to appropriate antibiotics. These data demonstrate that these children obtained clinically significant relief after tonsillectomy, and 33% experienced complete resolution of symptoms immediately following the procedure. All 9 children who underwent tonsillectomy, even those whose symptoms failed to improve after receiving antibiotics, reported reduced neuropsychiatric symptoms at all measured time points after tonsillectomy. This suggests that tonsillectomy offers a useful treatment alternative for children with PANDAS who incompletely respond to antibiotics.

A recently published prospective study15 looked at 112 patients with PANDAS, 32 of whom had previous tonsil and or adenoid surgery. The authors showed that PANDAS symptom severity and antibody titer levels did not differ between the surgical and nonsurgical groups. However, 22 of the 32 patients had undergone surgery prior to the development of neuropsychiatric symptoms, 10 of the patients received only an adenoidectomy, and 4 patients received only a tonsillectomy. While these findings seem to show that previous tonsil and/or adenoid surgery does not prevent a child from getting PANDAS, they do not address the question about whether extracapsular tonsillectomy with adenoidectomy diminishes PANDAS symptoms in comparison to antibiotics alone.

Our study is limited by its retrospective design and sample size of 10. The potential for recall bias exists because we have extracted historical accounts of symptom severity from parents. Because parents consented for surgery and were therefore invested in a positive outcome, they were more likely to form favorable perceptions. The absence of a control group makes it difficult to prove that posttonsillectomy improvement was not due to the natural course of the disease. Furthermore, the symptom severity scores that we used have not been validated and rely on potentially biased parental recollection of past symptoms. Nevertheless, this study shows statistically significant improved symptom scores at all time points after tonsillectomy in comparison to antibiotics alone. A prospective study could provide more persuasive evidence of the efficacy of tonsillectomy for patients with PANDAS, but such a study would be challenging because of both disease variability and the desire of most families to have surgical treatment.


Although current evidence is inconclusive, the data reported herein support previously described smaller case series and further strengthens the notion that tonsillectomy may benefit patients with PANDAS whose symptoms are not controlled with antibiotic therapy.

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Article Information

Corresponding Author: Daniel Demesh, MD, Department of Otorhinolaryngology–Head and Neck Surgery, Albert Einstein College of Medicine, 3400 Bainbridge Ave, Third Floor, Bronx, NY 10467 (

Submitted for Publication: August 10, 2014; final revision received September 17, 2014; accepted September 28, 2014.

Published Online: January 8, 2015. doi:10.1001/jamaoto.2014.3407.

Author Contributions: Dr Demesh had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: All authors.

Acquisition, analysis, or interpretation of data: Demesh, Bent.

Drafting of the manuscript: Demesh.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Demesh.

Administrative, technical, or material support: Bent.

Study supervision: Virbalas, Bent.

Conflict of Interest Disclosures: None reported.

Previous Presentation: This study was presented as a poster at the American Society of Pediatric Otolaryngology Annual Meeting; May 16, 2014; Las Vegas, Nevada.

Additional Contributions: Hillel W. Cohen, DrPH, MPH, Department of Epidemiology and Population Health, Albert Einstein College of Medicine assisted with data analysis, specifically for identifying the most appropriate statistical test for these data, and assisted in the analysis using SPSS for Windows (version 2.0). He was not compensated for his contributions.

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