June 2012

Translating Developmental Genetic Findings Into Obesity-Related Clinical PracticeAre We There Yet?

Author Affiliations

Author Affiliation: Department of Nutrition Sciences, University of Alabama at Birmingham.

Arch Pediatr Adolesc Med. 2012;166(6):576-577. doi:10.1001/archpediatrics.2012.704

For most individuals, reaching overweight or obesity status is the result of a process that is cumulative and progressive. Cross-sectional measurements of obesity-related traits are one-time indicators of an individual's historical trajectory of fat accumulation and, based on general scientific consensus, respond to continuous environmental, behavioral, and genetic factors. These factors individually and collectively act and interact in complex ways to lead to the progression of fat accumulation. A challenge confronted by the research community is the identification of statistically powerful samples and/or experimental designs to uncover the biological and nonbiological factors that affect changes in body composition parameters across the life span.

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