In the last decade pediatricians have come to recognize a form of acid intoxication occurring in children as a distinct clinical entity, the so-called acidosis.
This type is described by Abt1 as occurring in robust children who have been previously healthy. Following a period in which the child's weight remains stationary and in which dissatisfaction with the food is shown, the disease becomes manifested by diarrhea, vomiting and a febrile reaction lasting a few days, after which there occur abdominal distention, and pronounced dyspnea characterized by rapid, labored respiration of wide amplitude; the liver becomes palpable, with firm round edges, the urine contains albumin, casts and the acetone bodies; in a few days the child passes into coma which is apt to terminate fatally. On postmortem examination the liver and kidneys are found to have undergone fatty changes. Abt also enumerates a variety of clinical conditions in which the
LACKNER E, GAUSS H. ACIDOSIS IN CHILDREN, WITH REFERENCE TO THE PATHOLOGIC ANATOMY. Am J Dis Child. 1917;13(3):209-217. doi:10.1001/archpedi.1917.01910030002001