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August 1917


Author Affiliations

Assistant Professor of Physiologic Chemistry, University of Minnesota MINNEAPOLIS
From the Departments of Pediatrics and Physiology, University of Minnesota.

Am J Dis Child. 1917;14(2):98-104. doi:10.1001/archpedi.1917.01910080031003

It has long been known that the uric acid excretion in the urine of children during the first few days of life is both relatively and absolutely high. Reusing1 determined the daily excretion of this substance during the first seven days of life of six normal children and found that it reached its maximum of 0.083 gm. on the third day. He used the analytical method of Gowland Hopkins.2 Schloss and Crawford,3 using the procedure of Folin and Shaffer,4 determined the uric acid excretion of nine infants each day up to and including the ninth day, and found in four of the cases that the excretion reached its maximum on the third day; in two cases on the second day; in two cases on the first day, and in one case on the fourth day. Their results are confirmatory of Reusing's. Schloss and Crawford also pointed

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