Since the original publication, in 1910, by Rowntree and Geraghty1 of the results of their experimental work with phenolsuphenolsulphaein in determining the functional capacity of the kidney, the value of the test has received such ample confirmation as to establish it among the essentials for careful diagnosis in renal diseases.
It may be desirable to recapitulate briefly its rationale and practical limitations. No attempt has been made to cover all the literature on observations on adults, but all of Rown and Geraghty's publication have been consulted and enough of the more recent articles to see that their opinions are, in the main, corrobcorroborated by others.
Phenolsulphonephthalein is an ideal substance for the study of renal function, being practically nontoxic and nonirritating, readily absorbed and rapidly eliminated through the kidneys. Even the stron the kidneys. Even thet advocates of indigocarmin, oritphthaleinying the total function of both kidneys. Owing to its avidity
GITTINGS JC, MITCHELL A. THE PHENOLSULPHONEPHTHALEIN ELIMINATION IN INFANTS AND YOUNG CHILDREN. Am J Dis Child. 1917;14(3):174-188. doi:10.1001/archpedi.1917.01910090019002