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July 1918

FURTHER REPORT ON THE USE OF PERTUSSIS VACCINE CONTROLLED BY THE COMPLEMENT FIXATION TEST

Author Affiliations

MINNEAPOLIS
From the Department of Pediatrics and the Department of Bacteriology, University of Minnesota.

Am J Dis Child. 1918;16(1):30-33. doi:10.1001/archpedi.1918.01910130037004
Abstract

In a previous communication1 I gave a preliminary report on the prophylactic use of pertussis vaccine controlled by the complement fixation test. In this paper it was shown that, by means of the complement fixation test, it was possible to demonstrate specific antibody formation after the prophylactic injection of pertussis vaccine. The conclusions arrived at were as follows:

Our observations in seventeen cases would, theoretically, justify the prophylactic vaccination against pertussis. In none of the cases treated with the smaller doses could any antibodies be demonstrated, whereas, large doses, such as recommended by the New York City Health Department, showed antibodies in 44 per cent, of cases. The freshly prepared vaccines were, apparently, more effective than the stock vaccines, as 60 per cent, of the patients treated gave positive fixation reaction. From this it may be concluded that it is possible to immunize children against pertussis if sufficiently large doses

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