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September 1918

THE EFFECT OF INJECTIONS OF PITUITARY SOLUTION ON THE URINARY OUTPUT IN A CASE OF DIABETES INSIPIDUS

Author Affiliations

ST. LOUIS
From the Department of Pediatrics, Washington University Medical School, St. Louis, Mo.

Am J Dis Child. 1918;16(3):195-204. doi:10.1001/archpedi.1918.01910150064007
Abstract

The striking relief of symptoms in diabetes insipidus on injection of extracts of the posterior lobe and pars intermedia of the hypophysis cerebri has been known for some years, but no adequate explanation for the effect has yet been offered. Therefore, any new facts bearing on the action of pituitary solution should be made known.

A boy of 9½ years suffering from diabetes insipidus was studied in the St. Louis Children's Hospital in March, 1918. Attention is called to one of the results of this study. Injections of pituitary solution checked the rate of output of water and chlorids invariably; but checked the rate of output of urea, creatinin and uric acid little or none at all. The significance of this difference is not clear. Further study from this standpoint should be directed to other cases of diabetes insipidus, and to normal persons in whom artificial polyuria has been induced

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